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No one has been a late-night TV host longer than David Letterman, who retires Wednesday after 33 years. Here's what he told TV Critic Eric Deggans about leaving the Ed Sullivan Theater one last time.

Researchers in Seattle are busy cataloging what scientists have learned. For now that includes detailed information on 240 mouse cells. Next up: a data trove of details on human brain cells.

NYPD officer Peter Liang has been indicted for the death of Akai Gurley. Some in the Asian-American community support holding Liang accountable; others say he is being scapegoated because of his race.

Even after the psychological pain is effectively treated, damage from long years of depression may linger. It seems to double the risk of stroke among adults over age 50, research suggests.

Network officials are gathered in New York this week to present their new fall lineups to advertisers. Renee Montagne talks to Kim Masters, of The Hollywood Reporter and host of KCRW's The Business.

The Amtrak train derailment in Philadelphia is raising a lot of questions about safety. Doug Riddell, a retired locomotive engineer, says, "The first responsibility of any railroader is safety."

The Labor Department's investigation follows an NPR/Mine Safety and Health News series about the failure of federal regulators to collect millions in safety penalties at the nation's mines.

Republicans are critical of President Obama's foreign policy with the rise of the Islamic State militant group and the Iran negotiations. But the GOP faces its own challenges related to world affairs.

To study the draft Trans-Pacific Partnership text, senators have to go to the basement of the Capitol and enter a secured, soundproof room and surrender their cellphones.

There was a smile, an embrace, a big kiss and then... something terrible, but funny, happened.